Details Product Information
| Product Name | HLA Mouse |
|---|---|
| Strain Name | HLA Humanized Mouse |
| Advantages |
1. HLA polymorphism coverage, including humanized alleles such as HLA-A0201, A2402, and HLA-C0102. 2. CD8+ T cells remain activatable. |
| Application |
1. Vaccine evaluation 2. Drug development |
| Nomenclature | C57BL/6JMcl-B2m tm1(B2M/HLA-A02.01)/MCL |
* For research use only. Not intended for use in humans or animals, including clinical, therapeutic, or diagnostic purposes.
Modeling Principle
The mouse-derived B2m leader peptide sequence is retained. The mouse-derived intron 1 is preserved. All introns within the knock-in (KI) region of the donor are replaced with human sequences. The WPRE element is added at the 3’ end.
